I think it does. I'm finally down to using combinations of lens+film for that reason.
If i use a very fine-grained film, i'm careful to either use a lens with smooth/simple/uncomplicated bokeh to avoid double lines/nissen. If i use a grainy film, like Tri-X, the grain breaks up the bokeh and nissen isn't as easily noticed. Sometimes it even adds to the effect. I have a picture of Amelia Earhart in the 20s, probably shot with a 4x5, where the bokeh would have been horrid if shot with fine grained film and/or color film. But, the B+W grain makes it look nice. It's just 'classic' in some way.
This is an issue i started to believe was related to digital.... Bokeh seems to be far more egregious with digital images than with film.... Digital reveals the optics. Film grain makes it more graphic and painterly.
This is a recent shot, with a combination i'm going to be using a lot from now on.
I found it first in a series of pictures by another flickr member.....